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Gatenby VK, Kearney MT (2010) The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease

A glycosylated FGF21 variant, LY2405319, maintains the molecular size of endogenous FGF21 but improves its thermal stability and reduces aggregation by engineering an additional disulfide bond and a small number of point mutations into the molecule (291)

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