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It transitions from being primarily an energy-yielding pathway into a dynamic biosynthetic factory, redirecting carbon flux to support the massive demand for macromolecular synthesis - such as fatty acids, non-essential amino acids, and nucleotides - required for rapid proliferation

Moore et al., 2000), and similarly showed to induce ASD-like behaviors in mice and rats (Rodier et al., 1997

Importantly, NRN1-mediated axonal growth is neuron-type specific: it promotes outgrowth in projection neurons but does not affect interneurons (Nedivi et al., 1998)

Thiamine (Vitamin B1) supplementation may be considered for patients experiencing persistent vomiting, as deficiency can develop relatively quickly in this situation