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1 Introduction Schizophrenia (SZ) is a chronic brain disorder characterized by genetic heterogeneity and neuropathological alterations, with high mortality rates ( Current evidence from genetics, molecular neuropathology, and clinical studies underscores the importance of immune factors in both the pathogenesis and treatment of schizophrenia ( Figure 1 )

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It has also been demonstrated that NAD + can exacerbate high-fat diet (HFD)-induced lipid accumulation in mice through the SIRT1/AMPK/SREBP-1 signal pathway (Shehata et al

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