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Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice

GaMD simulations revealed that heparin binding affects the overall conformational dynamics of the SP trimer rather than the local flexibility of its residues

In fact, GSNO reductase-dependent oxidation of HMGSH is increased 8-fold in the presence of GSNO in vitro and more than 20-fold in crude lung and liver lysates