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If the deficiency goes untreated, severe neurologic effects may develop, so that the deficiency is clinically identified and treated early is very important

For the third cohort receiving 6 mg/kg DCR-PHXC, the mean maximal 24-h Uox reduction reached 76% (range: 58100%)

VFMC, VG, JT, CS, HE, YYB, CB, MZ, ART and FG designed experiments

(ii) iron-catalyzed auto-oxidation, and (iii) oxidase- and esterase-mediated peroxidation of polyunsaturated fatty acids (PUFA) (Yang and Stockwell, 2016