low glutathione in chronic fatigue syndrome The Role of Metabolism Illness Development and Its Potential Use as a Novel Therapeutic Target Glutathione: Pharmacological aspects and implications

Indeed, it was demonstrated that heterodimerization of 1-cysPrx with GSH-saturated GSTP results in S -glutathionylation of the oxidized cysteine in 1-cysPrx followed by subsequent spontaneous reduction of the mixed disulfide and restoration of enzymatic activity ( GSH AND NITROSATIVE STRESS Besides protecting against ROS, GSH is implicated in counteracting RNS-mediated damage

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doi: 10.1016/j.neuroscience.2012.11.021 354 Halon-GolabekMBorkowskaAKaczorJJZiolkowskiWFlisDJKnapNet al