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Zhou F-L, Zhang W-G, Wei Y-C, Meng S, Bai G-G, Wang B-Y, et al

They only found a peak of extracellular DA before the first intromission in the PM group

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Even small molecular drugs can barely cross the BBB, which is a major limitation for the treatment of central nervous system (CNS) diseases, such as Alzheimers disease and Parkinsons disease