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A 2025 systematic review of BPC-157 in orthopedic sports medicine acknowledged the compelling preclinical data while noting the absence of human clinical trials as a critical limitation

10.1254/jphs.fp0072161 65 KolovratM.GojkovicS.KrezicI.MalekinusicD.VrdoljakB.Kasnik KovacK.et al (2020)

On average, volunteers in the retatrutide clinical trial who received the study drug rather than a placebo lost an average of 70.3 pounds over about a year-and-a-half, with more than 45% of participants losing more than 30% of their body weight