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Analysis of glutathione synthetase activity in cultured amniocytes or chorionic villi [30]

If symptoms suggest deficiency but serum B12 looks normal, ask for a methylmalonic acid (MMA) test it detects cellular deficiency earlier

Eur J Biochem 156:569577 Britsch L, Heller W, Grisebach H (1981) Conversion of flavanone to flavone, dihydroflavonol and flavonol with an enzyme system from cell cultures of parsley