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Description

Immunity 46, 405420

The concept is that patients could achieve significant weight loss on higher doses and then step down to 4mg to maintain results with fewer side effects

Obesity represents itself as a challenge for hypothalamus-pituitary-thyroid axis since it has been hypothesized that hyperleptinemia, that often characterizes these patients, may increase the expression of TRH gene and thus TSH secretion [194]