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Firstly, they adhere to the bacterial cell wall, disrupting permeability and cellular respiration (298)

Nucleus-localized sirtuin 1 (SIRT1) migrates to mitochondria to exert its effects [125] and is another prevalent target in the context of ALD [125, 129,130,131,132,133] and MASLD [22, 117, 133]

Sulfate-reducing bacteria (SRB) are anaerobic microorganisms widely distributed in nature 22 and specific human ecological niches, including the gastrointestinal tract, oral cavity, and reproductive system 23,24

Further, a fraction of potentially harmful substances that are formed by the hepatic firstpass effect is transported to the lung which then acts as second line of defense