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Patients with a high mucus plug burden typically exhibit elevated markers of T2 inflammation, including sputum eosinophilia and increased fractional exhaled nitric oxide (FeNO), reflecting upregulation of IL-4/IL-13dependent pathways [28]

However, the IOM has set the UL for folic acid at 1.0 mg/day for adults [100, 108]

v-ATPase-induced shifts in pH may function as a signaling cue triggering broader metabolic reprogramming, such as nutrient sensing at the lysosome, and may phenocopy a nutrient-deprived or energy-stressed state, even in the presence of external nutrients 42