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Since serine and glycine are considered nonessential, their depletion can be tolerated in vivo

52 GalloS.GattiS.SalaV.AlbanoR.CostelliP.CasanovaE.et al (2014a)

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When methylation doesnt work properly, it can impact many aspects of health, including inflammation levels, fertility, hormones, detox ability, and even how you handle stress [3]