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Emerging role of the TCA cycle and its metabolites in lung disease

Meanwhile, GRh3 prevents NRF2 from entering the nucleus, thereby suppressing SLC7A11, resulting in GSH depletion and the accumulation of iron, ROS, and MDA, ultimately triggering ferroptosis in CRC cells [296]

[DOI] [PubMed] [Google Scholar] 125.Wang J., Li Y

This enzymatic process liberates Cbl, allowing it to bind to a glycoprotein known as the intrinsic factor (IF), which is synthesized by gastric parietal cells