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Their action signals the cell to modulate its response, through the recruitment of endogenous coping mechanisms, among which are an increased synthesis of antioxidants and of electrophile quenchers, the transcription of the necessary gene products and the production of reducing cofactors such as NADH/NADPH and ascorbate

Factors Influencing Enzyme Activity Within the Cycle In addition to gene expression regulation, the activity of enzymes within the methionine cycle is influenced by various factors, including cellular metabolite levels, nutrient availability, and signaling pathways

Some cysteine-containing peptides derived from these receptors do bind ascorbic acid and/or dehydroascorbic acid and the same peptides generally bind opioid compounds

Therefore, even if the complete protein is required for the full reaction, C-terminal region is able to cause similar hydrogen peroxide production as a major defense response