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Phytosomes are well suited for oral and topical administration and preparation techniques such as solvent evaporation, rotary evaporation, and lyophilization are commonly employed to bind plant extracts with phospholipids for improved pharmacokinetic properties and targeted therapeutic effects [89, 90]

It is important to bear in mind that the temperature during the trek is cold at night and hot during the day

an effect that is, in part, mediated by impaired NO activity [92,93]

There is so far no inflammatory marker that has been systematically found in PAIS, but it should be remembered that a persistent inflammation affecting an organ, e.g., neuroinflammation, may remain local and may only minimally be reflected in blood biomarkers