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Although these major steps likely remain true, the current model is still incomplete, as it does not include the most recently identified classes such as mPGES2, GHR, Metaxin, Hemerythrin, Iota, and Ure2p, just to cite classes present in plants

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[] Heavy metals, mainly lead, may also substitute bivalent cations such as calcium ion (Ca2+), magnesium ion (Mg2+), iron (II) (Fe 2 +) and monovalent cations such as sodium ion (Na+) and cause dysfunctions where these cations act as cofactors in various enzyme activities