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It is noteworthy that this antioxidant effect may be, at least in part, associated with the heat shock response pathway ( 5 Current research controversies and clinical translation challenges Current research on the protective effects of L-citrulline against heat stress-induced spermatogenic damage relies predominantly on animal models or in vitro cell systems ( Table 1 ) ( Table 1 Therapeutic effects of arginine/citrulline on heat stress-induced male reproductive damage

Current evidence supports excellent safety for long-term use with appropriate cycling

Tagitinin C activates nuclear translocation of Nrf2 and expression of HO-1, increases unstable iron pools and lipid peroxidation, and inhibits the growth of CRC cancer cells

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