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Current evidence indicates that, across multiple models, 4-HNE activates inflammasomes, promotes calcium overload, impairs autophagylysosome flux, and interferes with transcriptional regulation and mRNA stability by modifying nuclear or RNA-binding proteins (Xiao Liang, 2024

Mutations in MMAA , MMAB , and MUT (corresponding to cblA, cblB, and mut complementation groups) are associated with isolated methylmalonic aciduria, while mutations in MTRR and MTR (corresponding to cblE and cblG complementation groups) are associated with isolated homocystinuria

Metabolite information of the longissimus dorsi muscle in positive ion mode

Dose-dependent vasorelaxant effect of GSNO in coronary artery rings Figure 4a shows a representative schematic of the isolation of the septal branch of the left coronary artery and its mounting as a vascular ring in a wire myograph, in which a force transducer records changes in isometric tension over time (Fig