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Moreover, MET and MMP3 were verified as key downstream genes of ANRIL involved in SOC cell migration/invasion by microarray analysis and Western Blotting (Qiu et al., 2015)

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This hardwired regulatory mechanism together with the observation that only the simultaneous depletion of these three FOXO isoforms results in a cancer phenotype in mice [32, 113] clearly points to redundant tumor suppressor functions of these proteins in cancer