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(Luo et al., 2022) addressed this by using ECM-modified hydrogels (ECM-Gels) to load cartilage endplate stem cells (CESCs) overexpressing sphingosine kinase 2 (Sphk2)

Glutathione peroxidase 4 (GPX4) is a key lipid peroxidase that inhibits ferroptosis by catalyzing glutathione (GSH) to eliminate lipid peroxides, thus preventing lipid peroxidation in cell membranes and maintaining membrane stability (Yang and Stockwell, 2016