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Tirzepatide works as a dual GLP-1 and GIP receptor agonist, meaning it triggers multiple metabolic pathways to reduce appetite and improve blood sugar control

Notably, gene-expression studies have associated GHK-Cu with the modulation of thousands of genes tied to tissue remodeling and the inflammatory response, which is why it is studied as a foundational signal peptide in repair models

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After solubilization with detergent, affinity purification and reconstitution in peptidiscs 32 , the protein was purified by size exclusion chromatography (Supplementary Fig