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Neurons were treated with tetrodotoxin, picrotoxin, and strychnine to suppress action potential, GABA-dependent inhibition, and glycine-dependent inhibition

D.HsiaA.IzumiyaY.WuC.et al (2011)

And this occurred during a switch from Detroit water that the city been using for a period of decades to Flint River water which runs through the town - it's a little bit of a saltier water source, a little more corrosive - and once that water was put into the system, a perfect storm of corrosion was unleashed