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This analysis of AD through network pharmacology provides a promising roadmap for addressing the diseases multifaceted pathology, paving the way for innovative, multi-targeted therapeutic solutions (Figure 2)

Microglial activation can result in pro-inflammatory conditions, characterized by the secretion of pathological factors (such as IL-1, TNF-, IL-6, NO, and proteases), or in neuroprotective states, influenced by signals like IL-4, IL-10, IL-13, and transforming growth factor- (TGF-) [50]

The abdomen (at least 2 inches away from the navel) is a common site for subcutaneous NAD+ because it has a good layer of subcutaneous fat and tends to be less sensitive

Cobalamin is vital for many biological reactions in the body involving cell growth, protein synthesis, digestion and nutrient metabolism, production of red blood cells, and proper functioning of the brain and nervous system