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Description

Poorly perfused tumor regions can experience much more severe glucose depletion, with local glucose concentrations reported as low as ~0.10.4 mM in human colon and gastric cancers

Cakouros D, Isenmann S, Cooper L, Zannettino A, Anderson P, Glackin C, et al

T.RoyA.PahanK

The inhibition of 3.7 nM TGR with 250 M inhibitor, 100 M NADPH, and a 15 min pre-incubation at RT was measured to compare to the inhibition after the jump dilution