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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury (Fang et al., 2025)

In senescent cells, FOXO4 sequesters p53 in the nucleus, preventing it from triggering apoptosis

Acox3p preferentially oxidizes short-chain acyl-CoA, and Yarrowia lipolytica cells lacking Acox2p and Acox3p exhibited normal growth on a medium with glucose

These benefits include: Effective absorption- Injections of b12 have the advantage of entering the bloodstream directly, bypassing the digestive system completely