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Nonalcoholic Fatty Liver Disease (LOE = B) There is evidence that NAC may block hepatic lipid accumulation and provide therapeutic benefit against metabolic complications found in nonalcoholic fatty liver disease (NAFLD)

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Gastrointestinal disorders were not dependent on cagrilintide dose, with 1238 events occurring in 7 (58%) of 12 participants to 11 (92%) of 12 participants given cagrilintide 0.164.5 mg in combination with semaglutide 2.4 mg, compared with 50 events occurring in 19 (79%) of 24 pooled participants given placebo in combination with semaglutide 2.4 mg

Symptomatology (i.e., paresthesia, spontaneous pain, tactile allodynia and mechanical and thermal hypo/hyperalgesia) may improve and resolve spontaneously, or culminate in total loss of sensation and ultimately in foot ulceration and amputation