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Furthermore, Sema4D-Fc, the ligand for PlexinB1, is imported into the cell following treatment with the fluorescently tagged protein (Fig

The first breakpoint occurs at the downregulated isocitrate dehydrogenase (IDH) 1, which converts isocitrate into -ketoglutarate (-KG) in M2, resulting in citrate accumulation, facilitating the biosynthesis of fatty acids and prostaglandins in M1 macrophages [12]