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Description

Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities: laboratory tools for an early and differential diagnosis

The local production of IGF-1 is controlled primarily by GH and other hormones (e.g., parathyroid and thyroid hormones) (Bikle et al., 2009)

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The accumulation of ROS has been demonstrated to trigger the phosphorylation and activation of the key kinase p38 MAPK, suggesting that ROS is a potential activator of the MAPK signaling pathway [75]