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Study approval All necessary permits for the use of skin biopsies from L68Q- CST3 carriers, and records associated with samples as well as medical information, were obtained from the National Bioethics Committee of Iceland, reference numbers 04-046-S2 and 15-060-S1

At each time point, the results for each test with aspartame were compared with those with placebo, using a two-tailed Student t -test without correction for multiple comparisons

[] NAC has long been used for these purposes

Figure 1: Showed the right mandibular edentulous ridge of a patient diagnosed with CTN and the fabricated stent to cover the painful site Pharmacological methods Pharmacological treatments include antidepressants (e.g., SSRIs, SNRIs, TCAs) and anticonvulsants (e.g., gabapentin, carbamazepine), which suppress neuronal hyperexcitability