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FIGURE 2 As markers of oxygen-mediated protein damage, AOPPs have been identified as indicators of oxidative protein damage and proinflammatory mediators (78, 79)

Track dosing in a clear plan: starting dose, escalation steps, monitoring frequency, and stop rules for adverse events

198 GiacomucciL.RaddadiN.SoccioM.LottiN.FavaF

Sample processing for protein extraction and tandem LysC/trypsin digestion Cell pellets (510 million cells) were lysed in an 8 M urea buffer with protease and phosphatase inhibitors