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Research has investigated the mechanisms by which NNMT inhibition might increase energy expenditure, potentially through effects on mitochondrial function or uncoupling protein expression

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The original adipocyte research reported increased intracellular NAD following 5-Amino-1MQ exposure

In the obese state, increased levels of fatty acids and cytokines in circulation induce activation of inflammatory signalling pathways such as STAT3 (signal transducer and activator of transcription 3), p38 MAPK (p38 mitogen-activated protein kinases) and NFkB (nuclear factor kappa-light-chain-enhancer of activated B cells) in metabolic tissue 35,36