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doi: 10.1038/nature22071 23 RickartAJDrummond-HayVSuchakASadiqZSebireNJSlaterOet al

Cancer Res (2020) 80(7):143850

Similar to METTL3, METTL14, another m 6 A methyltransferase, installs m 6 A modification on the 5'UTR of SLC7A11 mRNAs to facilitate their degradation in a YTHDF2-dependent manner, and hypoxia induces the downregulation of METTL14 by regulating HIF-1 levels, thus protecting hepatocellular carcinoma (HCC) cells from ferroptosis[161]