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The mitochondrial DOX-Fe 2+ complex induces triggers lipid peroxidation, resulting in mitochondria-dependent ferroptosis and decreased cardiac function in mice, which is reflected in significantly reduced left ventricular ejection fraction and myocardial fibrosis

More recently, theobromine displayed a preventive effect against interleukin (IL)-1-induced chondrocyte dysfunction through the reduction in the IL-1-induced production of cellular ROS and inflammatory mediators, including ciclooxigenase 2 (COX-2), prostaglandin E2, and NF-KB [217]