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[DOI] [PMC free article] [PubMed] [Google Scholar] 221.Bedrnek J., Laknerov I., Linhartov Z., Kadlec J., Samkov E., Brta J., Brtov V., Mrz J., Peek M., Winterov R., et al

A Phase II study in patients with PSC demonstrated the plausible effectiveness of the 24-norursodeoxycholic acid derivative with significant improvement in AP and bilirubin levels

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With respect to implications for treatment, serotonergic agents have multiple relevant therapeutic mechanisms, including blocking tau and A and promoting synaptic plasticity