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10.1007/s10495-010-0524-6 Apoptosis 50 KwonE

Supporting the hypothesis that the salvage pathway has a major function in regulating intracellular BH4 levels, the same investigators observed that despite administering the unnatural diastereomer 6 S -BH4 to mice, a large proportion of the deposited BH4 (more than 95% was in the liver) was in the form of the 6 R -diastereomer [81,33]

Oxidative stress has been shown to influence sleep regulation through its effects on neurotransmitter systems, particularly those involving GABA and serotonin (Tsermpini et al