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Due to its shorter sequence, TB-500 offers enhanced metabolic stability and amenability to synthetic optimization compared to the parent protein

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that plays a critical role in cellular metabolism and energy homeostasis

Participants receiving 1 mg per day of AOD 9604 lost approximately 2.6 kg compared to 0.8 kg in the placebo group

Understanding these multifaceted benefits helps explain why this peptide has generated significant interest in both research and clinical settings