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Similar content being viewed by others Background Oxidative stress (OS) is a toxic cellular status due to the imbalance between oxidant and antioxidant mechanisms resulting from increased production of oxidants, a dysfunction in the antioxidant system, or both [1, 2]

von Laffert, M., Stadie, V., Wohlrab, J

Cytokine inhibitors and antioxidants, such as those explored in preclinical models, reduce inflammation-driven bone turnover and VC, offering a complementary approach to conventional therapies (100)

Structurally, CAPS2 contains both a dynactin 1 interaction domain, suggesting that it may coordinate motor complex recruitment, and the Munc13-1 homologous domain, which is implicated in vesicle priming