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Psoriatic mice treated with SFN exhibit decreased keratinocyte differentiation and reduced cutaneous inflammation Keratin 16 (K16) and keratin 17 (K17) are established markers of excessive keratinocyte hyperproliferation in psoriasis and are known to promote T-cell activation and psoriasis development [17, 18]

Attesting to such a role, specific deletion of the perivascular pool of AQP4 significantly reduces the size of experimentally induced edema 565 , mimicking the effect of a global AQP4 knockout 566

Unlike phosphodiesterase-5 (PDE5) inhibitors such as sildenafil, PT-141 works centrally in the brain rather than directly on penile blood vessels

Indirect telomere protection : By reducing oxidative damage that accelerates telomere shortening, carnosine may indirectly help preserve telomere length