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Rhee CK, Kang CM, You MB, et al

VEGF, vascular endothelial-derived growth factor

Cinchonine and cinchonidine alleviate cisplatin-induced ototoxicity by regulating PI3K-AKT signaling

### What the Clinical Data Shows Analysis of STEP trial body composition data published in *Diabetes, Obesity and Metabolism* (2023) revealed: - Approximately **6075% of total weight lost on semaglutide was fat mass** - The remaining 2540% included water, glycogen, and some lean tissue - Lean mass loss was proportional to what is expected with any significant weight reduction ### How Bodybuilders Can Optimize Muscle Preservation on GLP-1 Peptides The key insight for the bodybuilding community is that lean mass loss on GLP-1 peptides is **highly modifiable** through training and nutrition