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The inhibition of Lps-induced production of inflammatory cytokines by Hsp70 involves inactivation of the NF-b pathway but not the MAPK pathways

When animals were treated with the mitochondria-targeted MnSOD mimetic Mito-TEMPO, the prevention of peroxynitrite formation due to superoxide dismutation eliminated necrotic cell death 6 h after APAP administration with no evidence of apoptosis [29, 58]