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Such agents may be classified into five groups based upon their chemical structure: para-amino benzoates

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They are FDA-approved and have a slower degradation rate than PBCA, allowing for a more sustained delivery [148,149]

Early diagnosis is considered as the key improvement index for the most desirable outcomes (i.e., reduced joint destruction, less radiologic progression, no functional disability, and disease modifying anti-rheumatic drugs (DMARD)-free remission) as well as cost-effectiveness as the first 12 weeks after early symptoms occur is regarded as the optimal therapeutic window