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J Mol Med

Research Highlights Metabolic Regulation and Anti-Obesity Effects: Potent inhibition of nicotinamide N-methyltransferase (NNMT) increases cellular NAD and S-adenosylmethionine (SAM) levels, enhances polyamine flux, boosts energy expenditure, and suppresses lipogenesis

V.SureshJ.BhamidipatiR

This may lead to a less efficient oxidative phosphorylation process, resulting in the production of more free radicals and reactive oxygen species (ROS) (Reid et al., 2018)