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We discovered that a PD indication can suddenly become evident and problematic when one or more of these accelerators are introduced to a long-standing instance of constant microtrauma that has never previously displayed symptoms

Advanced in vitro models To bypass the limitations of 2D cultures, advanced in vitro culture systems have been developed, including the use of 3D organized structures, known as organoids, and kidney microphysiological systems (MPS) that can recreate fluidic characteristics found in vivo (Fig