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[] Furthermore, BNIP3, a critical mitophagy receptor, is a known transcriptional target of FOXO3, which itself can stimulate PGC-1 expression

This genetic metabolic block severely impairs the body's ability to produce cellular energy and clear out neurotoxins, directly contributing to the hallmark symptoms of ME/CFS, including profound post-exertional malaise (PEM) and unrefreshing sleep

Several functions that involve B Vitamins include: Metabolism (energy) Neurological function DNA production & repair Nerve and neurotransmitter function Digestion & appetite Hormone & cholesterol production Infection prevention Eye/vision health Blood cell production Cell growth & division B vitamins are crucial for energy and metabolism