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A recent study found that NRF1 can also regulate GPX4 [12]

Indeed, many cancer cells exhibit an inherent susceptibility to ferroptosis because of their altered metabolic states, iron levels and membrane composition 11,12,13,14

Figure 3 Oligomeric A 40 Induces Inflammation Which Is Modulated by GGC Treating human brain cells with oligomeric A 40 significantly decreased the level of the anti-inflammatory cytokine IL-10 (Figure 4A) and increased the levels of the pro-inflammatory cytokines, TNF-, IL-6 and IL-1 compared to non-treated cells (Figures 4BD)