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Small, geographically dispersed patient populations and high phenotypic variability often lead to slow recruitment, limited statistical power, and extended trial durations 30,31,32,33,34

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The studied figure of ~1,485 mcg for a 70 kg adult was a slow intravenous injection given in a sleep laboratory under polygraphic monitoring it has never been administered subcutaneously to a human in any published study, and rendering it as a number of units on an insulin syringe would convert a monitored hospital procedure into an at-home target it was never validated as