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Populations to avoid: Pregnant and breastfeeding individuals, individuals with active neuroendocrine conditions, and those on ACTH-axis medications should not use DSIP without specialist guidance

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These cardiovascular effects suggest potential applications in ischemic heart disease, peripheral vascular disease, and vascular injury, though clinical translation requires confirmation of effects in human subjects

Vitamin B12 is necessary for red blood cell production, energy metabolism, and the conversion of propionate to glucose during exercise, contributing to normal stamina and metabolic function