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Burtscher J, Mallet RT, Pialoux V, Millet GP, Burtscher M

The TB 500 peptide is used exclusively in research settings to study the biological activities attributed to the parent Thymosin Beta-4 protein, particularly its role in actin regulation, cell migration, and tissue repair processes the same regenerative, anti-inflammatory activity profile that places it on many a list of anti-inflammatory peptides researchers track

This design harnesses the elevated intracellular glutathione (GSH) levels in tumor cells to cleave the linker, releasing the active PROTAC for FOLR1-dependent ALK degradation