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However, it was not until experimental work in the late nineteenth and the twentieth century that pathophysiological mechanisms of this relationship started to unravel, instigating a shift leading to the understanding that behavioral changes are an integral consequence of chronic liver insufficiency and disease

However, reduced effects were seen in replicate exposures kept under laboratory lighting, thereby highlighting the importance of using appropriate spectral quantity and quality in laboratory tests so that they do not underestimate toxicity in the field (Martinez et al., 2007)